Mac and Cheese Meatloaf Casserole

Mac and Cheese Meatloaf Casserole is a hearty and comforting dish that combines two all-time favorites—creamy macaroni and cheese with savory, flavorful meatloaf—baked together in one delicious casserole. It’s a perfect family-friendly meal that’s both filling and packed with comforting flavors.

Why You’ll Love This Recipe

I love this recipe because it brings the best of both worlds in one dish, making dinner easy and satisfying. The cheesy macaroni balances perfectly with the seasoned meatloaf layer, creating a warm and rich casserole that everyone enjoys. It’s an easy way to make meatloaf feel new and exciting, and it reheats beautifully for leftovers.

Ingredients

• 1 pound ground beef

• 1 small onion, finely chopped

• 1 egg

• 1/2 cup breadcrumbs

• 1/4 cup ketchup

• 1 teaspoon Worcestershire sauce

• 1/2 teaspoon garlic powder

• Salt and pepper to taste

• 2 cups cooked macaroni pasta

• 2 cups shredded cheddar cheese, divided

• 1 cup milk

• 2 tablespoons butter

• 2 tablespoons all-purpose flour

• 1/2 teaspoon mustard powder (optional)

(Here’s a tip: Check out the full list of ingredients and measurements in the recipe card below.)

Directions

1. Preheat the oven to 350°F (175°C). Grease a 9×9-inch baking dish.

2. In a bowl, combine the ground beef, chopped onion, egg, breadcrumbs, ketchup, Worcestershire sauce, garlic powder, salt, and pepper. Mix until just combined. Set aside.

3. Prepare the macaroni and cheese: In a saucepan, melt the butter over medium heat. Stir in the flour and cook for about 1 minute to make a roux. Gradually whisk in the milk, cooking until the sauce thickens.

4. Remove from heat and stir in 1 1/2 cups of shredded cheddar cheese until melted and smooth.

5. Combine the cooked macaroni with the cheese sauce and set aside.

6. Spread half of the mac and cheese mixture evenly in the bottom of the prepared baking dish.

7. Shape the meat mixture over the mac and cheese layer, pressing it down gently.

8. Spread the remaining mac and cheese over the meatloaf layer.

9. Sprinkle the remaining 1/2 cup cheddar cheese on top.

10. Bake for 45-50 minutes, or until the meatloaf is cooked through and the cheese on top is golden and bubbly.

11. Let the casserole rest for 10 minutes before serving.

Servings and Timing

This recipe serves 6 people and takes about 1 hour 15 minutes, including prep and baking time.

Variations

I like to add diced bell peppers or mushrooms to the meatloaf mixture for extra flavor and texture. Swapping ground beef for ground turkey or chicken is a leaner option. Using different cheeses like Monterey Jack or gouda can add a unique twist. For a spicy kick, adding a dash of hot sauce or red pepper flakes works well.

Storage/Reheating

Leftovers keep well in an airtight container in the refrigerator for up to 3 days. I reheat individual portions in the microwave or oven until warmed through, adding a little extra cheese on top if desired.

FAQs

Can I prepare this casserole ahead of time?

Yes, I often assemble it the day before and refrigerate, then bake when ready.

Can I freeze leftovers?

Absolutely. I freeze portions in airtight containers for up to 2 months and thaw overnight before reheating.

What pasta works best?

Elbow macaroni is classic, but small shells or penne work well too.

Can I make this recipe gluten-free?

Yes, by using gluten-free breadcrumbs and flour, it’s easy to adapt.

How do I ensure the meatloaf stays moist?

Adding ketchup and Worcestershire sauce, along with not overmixing the meat, helps keep it tender.

Conclusion

Mac and Cheese Meatloaf Casserole is a comforting, crowd-pleasing dish that combines two beloved comfort foods into one easy meal. Its cheesy layers and savory meatloaf make it both hearty and satisfying, perfect for family dinners or potlucks. I love how simple it is to prepare and how well it keeps as leftovers—definitely a recipe I keep coming back to.